Conquering Diseases

Study of a New Investigational Drug Designed to Treat Crohn’s Disease


Seeking patients with moderate to severe Crohn’s Disease. This study tests two amounts (doses) of a drug given by monthly injection compared with no treatment (placebo).


Participants of this study will get monthly injections with either 25mg or 75mg of the study drug or a placebo (fake medicine) over 4 months. You do not choose or know what dose, if any, you receive. Any side effects and benefits will be noted by patient report and through tests like blood draws, physical exam by the study doctor and examination of the colon by endoscopy. During the study, if you are eligible, you may choose to join a follow on study or not.

What we're hoping for

To learn if the study drug, SHP647, works to treat moderate to severe Crohn’s Disease and is safe for the patient compared with no treatment (placebo).

Additional Information Identifier: NCT03566823

 Principal Investigator

JeanMarie  Houghton, MD, PhD

University of Massachusetts Medical School

 Study Contact

The Gastrointestinal Research  Office



UMMS University Campus

55 Lake Ave North 

Worcester,MA 01655