We are studying whether combining an investigational drug with standard chemotherapy and surgery is more effective than just the standard chemotherapy and surgery in treating bladder cancer.
50 Studies found
Seeking men & women 18 - 70 years who have a history of node positive or high risk node negative breast cancer.
Seeking Male and Female age 0-25 years who may have cancer or another condition that is characterized by abnormal cell growth but may be benign (not cancer), or may already have been diagnosed with cancer.
This study is collecting tumor tissue, body fluids and blood samples from patients undergoing biopsies or surgery to gain a better understanding of different cancers.
Seeking people aged 3 to 25 with newly-diagnosed high-grade glioma whose brain tumor has been genetically tested to show that it does not have the H3, K27M and BRAF mutations for a study of an investigational drug. The study will compare whether adding the investigational drug to radiation and maintenance therapy is better than the usual treatment.
Study Of An Investigational Drug For Relapsed Or Refractory Cd22+ B-Acute Lymphoblastic Leukemia (B All)
Seeking children and young adults whose CD22+ B-Acute Lymphoblastic Leukemia (B ALL) has come back (relapsed) after treatment or has not responded (refractory) for a study of an investigational drug. While the investigational drug has been approved for use adults with leukemia, it has not yet been approved for use in children.
Seeking men and women who are or have been smokers and are at greater risk for lung cancer for a study to improve lung cancer screening
Study Of Chemotherapy For Children And Young Adults With High-Risk B-Cell Acute Lymphoblastic Leukemia (B-All)
Children and young adults up to age 25 with High-Risk B-cell acute lymphoblastic leukemia (B-ALL) sought for a study of an investigational drug in combination of chemotherapy based on individual disease characteristics to improve 5-year disease-free survival (DFS).
Seeking children and young adults 31 years old or younger who have been newly diagnosed with standard risk B-cell Acute Lymphoblastic Leukemia (B-ALL), Down syndrome B ALL or localized B-cell Lymphoblastic Lymphoma (B-LLy) for a study of chemotherapy.
People with a type of Diffuse Large B-Cell Lymphoma called "Activated B Cell" that did not get better with treatment or has returned after previous treatment sought for a study of whether adding in an additional investigational drug makes the therapy better, the same or worse than the usual approach.
The study is open to men & women with triple negative breast cancer that have received chemotherapy prior to surgery, then had surgery to remove the breast cancer, and viable tumor was still seen in the surgery specimen.
This study is looking at an experimental treatment for patients with anal cancer who have been treated with standard chemotherapy and radiation.
This study will evaluate the safety and effectiveness of an investigational drug for multiple types of advanced cancer that haven't responded to treatment and have spread to other parts of the body (metastatic).
Study Of An Investigational Drug For Metastatic Prostate Cancer That Is Resistant To Hormone Treatment
Seeking men whose prostate cancer has spread beyond their prostate despite treatment with androgen deprivation therapy (also known as castration resistant prostate cancer) for a study comparing the usual treatment to the usual treatment with an experimental drug on controlling the cancer.
Seeking men and women aged 18 and older whose colon, peritoneal, or rectal cancer will be treated with surgery (resectable) for a study of an investigational drug to make the cancer cells glow under infrared light.
Seeking persons aged 12 and older who have a bloodstream infection related to a central venous catheter (CVC) for a study of an investigational drug to disinfect the catheter.
Men and women with advanced HPV throat cancer sought for a study comparing the outcomes for people who get chemotherapy and radiation followed by experimental immunotherapy to those who get chemotherapy and radiation followed by observation.
Seeking men and women aged 18 and older whose head and neck squamous cell carcinoma has spread to other parts of the body (metastatic), can't be treated with surgery or radiation, and has not yet been treated for cancer or has returned or got worse after being treated (recurrent) for a study of an investigational drug.
Seeking men and women with pancreatic cancer for a study of an experimental device used along with chemotherapy to evaluate whether it decreases cancer cell growth.
Seeking men and women with locally advanced pancreatic cancer that can't be completely removed with surgery for a study of an investigational drug added to the standard chemotherapy.
Seeking men and women who have been diagnosed with melanoma skin cancer and will have surgery to remove it for a study of whether starting the experimental drug before surgery is better or worse than starting the drug after surgery.
Study Of The Addition Of An Investigational Drug To Treatment Following Stem Cell Transplant For Multiple Myeloma
Seeking men and women who have had stem cell transplant for their multiple myeloma for a study of an investigational drug to be added to the usual maintenance treatment.
Seeking women with advanced high-grade epithelial ovarian, primary peritoneal, or fallopian tube cancers with high folate-receptor-alpha expression for a study comparing an investigational drug to chemotherapy.
Study Of An Investigational Combination Of Drugs For Advanced Non-Squamous Non-Small Cell Lung Cancer
Seeking men and women whose non-squamous non-small cell lung cancer tumor has a STK11 gene mutation for a study of an investigational drug combination.
Study Of An Experimental Blood Test To Predict The Benefit Of Chemotherapy Following Surgery For Colon Cancer
Seeking men and women who have early stage colon cancer that has been treated with surgery for a study of an experimental test using cancer cells in the blood to predict the benefit of chemotherapy.
Seeking men and women with cancer of the esophagus or gastric junction for a study of whether a blood sample analyzed to find evidence of a cancer tumor (liquid biopsy) might be a useful tool to predict how well the cancer has responded to treatment.
Study Of A Targeted Investigational Drug For Non-Small Cell Lung Cancer That Has Come Back Or Spread After Treatment
Seeking men and women whose non-small cell lung cancer has come back or spread after treatment for a study of an investigational drug that is targeted for tumors with a specific biologic marker.
Study Of The Safety And Efficacy Of An Investigational Drug For Inoperable Early Stage Non Small Cell Lung Cancer
Seeking men and women with early stage (I/IIA) non small cell lung cancer that can't be removed with surgery for a study of an experimental drug.
Seeking men or women living with cancer of the bile duct, also known as cholangiocarcinoma, who need to change therapies for a study of the safety and effectiveness of an investigational drug either on its own or in combination with other drugs.
Seeking men and women with HER2-positive breast cancer that has spread to other parts of the body (metastatic) for a study of an investigational drug.
We are studying how well active surveillance, or two different combinations of chemotherapy work in treating children 11 and older and adults under age 25 with germ cell tumors.
Seeking women with ovarian cancer for a study of whether adding investigational drugs to the usual treatment delays or prevents ovarian cancer from coming back
Seeking Male & Female patients age 0-30 years who have a kidney tumor (an abnormal growth of cells or tissues in the kidney that may be benign or malignant) or a tumor outside the kidney called a malignant rhabdoid tumor or an extrarenal Wilms tumor.
Seeking adults with localized (has not spread) kidney cancer who plan to undergo surgery to remove all or part of their kidney (nephrectomy) for a study comparing treatment with or without an investigational immunotherapy drug before surgery
This study is looking at using different experimental treatment methods for children diagnosed with Acute Myeloid Leukemia (AML) and Down Syndrome (DS) based on how well they respond to their first treatment.
We are seeking people whose liver cancer was removed through surgery and radiation therapy for a study of an investigational drug to assess if it prevents the cancer from returning
Seeking adult men & women whose tumor cells have a change in a gene called ALK that causes the cells to grow and spread.
Seeking adults with non-small cell lung cancer for a study comparing immunotherapy to targeted therapy based on tumor characteristics
Study Of Immunotherapy Alone Or In Combination With Chemotherapy For Advanced Nonsquamous Non-Small Cell Lung Cancer
Non-squamous non-small cell lung cancer patients whose cancer has been tested to be PD-L1 positive (a kind of tumor marker) sought for study comparing two usual approaches to treatment.
Seeking volunteers who received immunotherapy, but whose non-small cell lung cancer has spread outside their lungs and either their tumor sample biomarker does not match one of the open treatment studies or they were not a candidate for a biomarker-matched study for a study of an investigational drug combination.
Addition Of An Investigational Drug To The Usual Treatment For Limited Stage Small Cell Lung Cancer (Ls-Sclc)
Men and women with limited-stage small cell lung cancer, which has not spread outside of their chest area sought for a study comparing how cancer responds when adding an investigational drug to the usual treatment for small cell lung cancer
Seeking male and female children ranging from 0-18 months of age diagnosed with non-high risk neuroblastoma.
This study is for patients who may have neuroblastoma, a tumor of nerve cells typically found in the stomach, chest or neck of young children. This is a data and sample collection study to help us better understand this disease.
Volunteers who are participating in the NMTRC014 research study for treatment of neuroblastoma survivors who are in remission are sought for a research study of how the study drug is absorbed into the the body.
This study is collecting information from patients who are at a high risk of developing pancreatic cancer based on family history or genetic mutations to see if a pancreatic cancer screening blood test can be developed.
This study is looking at an experimental treatment for prostate cancer that has spread to other parts of the body and has grown even though treatments to lower the amount of male sex hormones are being used to manage the cancer.
Volunteers with advanced prostate cancer that has spread to their bones sought for a study of an investigational drug to assess if it stops the cancer from growing
This study is looking to compare different surgical options for treating patients with rectal cancer.
Seeking adults with rectal cancer requiring surgery for a study comparing an investigational surgery to the standard surgery technique
Seeking male & female patients who have been diagnosed with rhabdomyosarcoma (cancer that forms in the soft tissues, such as muscle).