Conquering Diseases

168 Studies found

Aortic Aneurysm

Aortic Aneurysm Repair Using Endovascular Surgery and Custom Made Devices

Seeking men and women over the age of 18 who have been diagnosed with an aortic aneurysm (bulging of the vein that carries blood to your heart) that because of their anatomy can't be treated using an FDA-approved graft. This study would use endografts that are customized by the doctor to the anatomy of each patient to treat these complex aortic aneurysms.

Atrial Fibrillation

Autism Spectrum Disorder

Gender

Male/Female

Age

5-17 years

Compensation

Offered

Image of Jean Frazier

Autoimmune Disease

Autoimmune Disease

Registry To Study Genetic Origins Of Multiple Sclerosis

Seeking people who been diagnosed with Multiple Sclerosis (MS) or a similar immune disorder of the central nervous system or their immediate family members for a study to better understand what causes these diseases and perhaps improve treatment.

Healthy Volunteers Wanted.

Autoimmune Skin Disease

Bladder Cancer

Bone Joint and Muscle Diseases

Bone Joint and Muscle Diseases

Bone Joint and Muscle Diseases

Study Of Inflammatory Arthritis

Seeking adults who have inflammatory arthritis and who are willing to provide data by answering questionnaires, giving a blood sample and donating leftover tissue samples for a study to help researchers better understand inflammatory arthritis.

Bone Joint and Muscle Diseases

Bone Joint and Muscle Diseases

Bone Marrow Transplant

Brain and Spinal Cord Diseases

Study Of Stress Reduction In Multiple Sclerosis

Seeking men and women with Multiple Sclerosis for a study of the role of stress in multiple sclerosis and whether an 8-week mindfulness-based stress reduction (MBSR) program effects your sense of well-being, stress level, and how it may change your brain.

Brain and Spinal Cord Diseases

Gender

Male/Female

Age

Adult

Compensation

Offered

Image of Andrew Bouley

Brain and Spinal Cord Diseases

Gender

Male/Female

Age

Adult

Compensation

Offered

Image of Andrew Bouley

Brain and Spinal Cord Diseases

Brain and Spinal Cord Diseases

Gender

Male/Female

Age

Adult

Compensation

None

Image of Kara Smith

Brain and Spinal Cord Diseases

A Study Comparing Two Ways Of Treating Patients With Brain Injury

This study is enrolling men and women who have had a traumatic brain injury in order to compare outcomes when medical care is delivered based on either monitoring the pressure in the brain or monitoring both the pressure in the brain and the amount of oxygen in the brain.

Brain and Spinal Cord Diseases

Brain and Spinal Cord Diseases

Brain and Spinal Cord Diseases

Brain and Spinal Cord Diseases

Multi-Arm Optimization Of Stroke Thrombolysis (Most)

Seeking men and women who are within the first few hours of experiencing an ischemic stroke (caused by a blood clot blocking blood flow to the brain) for a study comparing medication combinations to reduce the impact of the stroke.

Brain and Spinal Cord Diseases

Brain and Spinal Cord Diseases

Gender

Male/Female

Age

50 and older

Compensation

None

Image of Majaz Moonis

Brain Aneurysms

Nano Registry

Seeking Men and Women 18-90 years old who have a small ruptured or un-ruptured aneurysm in the head.

Brain Aneurysms

Brain Aneurysms

Brain Aneurysms

Gender

Male/Female

Age

18-80 years

Compensation

None

Image of David Rex

Brain Aneurysms

Brain Injury

Impact Of Fever Prevention In Brain Injured Patients

Seeking patients who have suffered a brain injury like ischemic stroke, intracerebral hemorrhage or subarachnoid hemorrhage for a study of an investigational medical device to prevent fever while in the hospital

Breast Cancer

Breathing Study

Cancer Genetics

Gender

Male/Female

Age

0-25 years

Compensation

None

Image of Stefanie Lowas

Cancer Genetics

A Study of Cancer Tumors (AVATAR)

This study is collecting tumor tissue, body fluids and blood samples from patients undergoing biopsies or surgery to gain a better understanding of different cancers.

Cancer Research

Study Of An Investigational Drug For High-Grade Glioma In Children And Young Adults

Seeking people aged 3 to 25 with newly-diagnosed high-grade glioma whose brain tumor has been genetically tested to show that it does not have the H3, K27M and BRAF mutations for a study of an investigational drug. The study will compare whether adding the investigational drug to radiation and maintenance therapy is better than the usual treatment.

Gender

Male/Female

Age

3- 25

Compensation

None

Image of Stefanie Lowas

Cancer Research

Gender

Male/Female

Age

All

Compensation

None

Image of Stefanie Lowas

Cancer Research

Gender

Male/Female

Age

1-25

Compensation

None

Image of Stefanie Lowas

Cancer Research

Gender

Male/Female

Age

31 or younger

Compensation

None

Image of Stefanie Lowas

Cancer Research

Study To Improve Lung Cancer Screening

Seeking men and women who are or have been smokers and are at greater risk for lung cancer for a study to improve lung cancer screening

Healthy Volunteers Wanted.

Cancer Research

Cancer Research

Study Of An Investigational Drug For Advanced Cancer

This study will evaluate the safety and effectiveness of an investigational drug for multiple types of advanced cancer that haven't responded to treatment and have spread to other parts of the body (metastatic).

Cancer Research

Cancer Research

Cancer Research

Cancer Research

Cancer Research

Gender

Male/Female

Age

18 and older

Compensation

None

Image of Madhavi Toke

Cancer Research

Cancer Research

Cancer Research

Cancer Research

Cancer Research

Cancer Research

Cancer Research

Study Of Liquid Biopsy Cancer Screening For Esophageal Cancer

Seeking men and women with cancer of the esophagus or gastric junction for a study of whether a blood sample analyzed to find evidence of a cancer tumor (liquid biopsy) might be a useful tool to predict how well the cancer has responded to treatment.

Cancer Research

Cancer Research

Study Of An Experimental Drug For Melanoma Skin Cancer

Seeking men and women who have been diagnosed with melanoma skin cancer and will have surgery to remove it for a study of whether starting the experimental drug before surgery is better or worse than starting the drug after surgery.

Cancer Research

Cancer Research

Cancer Research

Cancer Research

Gender

Male/Female

Age

12 and older

Compensation

Offered

Image of Jennifer Daly

Chronic Pancreatitis

Chronic Pancreatitis

Cystic Fibrosis

Gender

Male/Female

Age

All

Compensation

None

Image of Ted Kremer

Cytomegalovirus (CMV)

Gender

Male/Female

Age

Child

Compensation

Offered

Image of Laura Gibson

Degenerative Spine Disease

LimiFlex Control Site Study

Seeking adults with degenerative spondylolisthesis with lumbar spinal stenosis whose doctors have recommended back surgery to address the pressure on your spinal cord or spinal nerves

Gender

Male/Female

Age

Adult

Compensation

Offered

Image of Michael Stauff

Developmental Disorder

Gender

Male/Female

Age

12-16

Compensation

None

Image of Carol Curtin

Digestive and Liver Diseases

Digestive and Liver Diseases

Gender

Male/Female

Age

All

Compensation

None

Image of Krunal Patel

Digestive and Liver Diseases

Gender

Male/Female

Age

Adult

Compensation

None

Image of Deepika Devuni

Digestive and Liver Diseases

Gender

Male/Female

Age

Adult

Compensation

None

Image of David Cave

Digestive and Liver Diseases

Laser Fistula Study

Seeking Men and Women 18-65 years old who have a fistula-in-ano that needs treatment.

Digestive and Liver Diseases

Digestive and Liver Diseases

Alcoholic Hepatitis Network Observational Study

Seeking healthy volunteers who either drink less than 1 drink per week on average or at least 3 drinks per day for a study collecting biological samples (blood, urine, and stool) and health information to better understand alcoholic hepatitis.

Healthy Volunteers Wanted.

Digestive and Liver Diseases

Eye and Vision Diseases

Germ Cell Cancer

Gender

Male/Female

Age

11-24 years

Compensation

None

Image of Stefanie Lowas

Heart and Blood Vessel Diseases

Heart and Blood Vessel Diseases

Gender

Male/Female

Age

Adult

Compensation

None

Image of Jeffrey Shih

Heart and Blood Vessel Diseases

Heart and Blood Vessel Diseases

Heart and Blood Vessel Diseases

Heart and Blood Vessel Diseases

Heart and Blood Vessel Diseases

Heart and Blood Vessel Diseases

Study Of An Investigational Drug To Reduce Brain Swelling Caused By A Stoke

Seeking men and women who are within 10 hours from the time they started to have stroke symptoms for a study of how well people who get the investigational drug in additional to the usual treatment recover compared to people who get a medicine without any active drug (placebo) in addition to the usual treatment.

Heart and Blood Vessel Diseases

Heart Artery Blockage

Heart Attack

Gender

Male/Female

Age

Adult

Compensation

None

Image of Craig Smith

Hepatitis C Infection

Hormonal Diseases and Diabetes

Gender

Male/Female

Age

18 and over

Compensation

Offered

Image of Dale Greiner

Infectious Diseases

Infectious Diseases

Gender

Male/Female

Age

Adult

Compensation

Offered

Image of John Haran

Infectious Diseases

Study Of How The Flu Affects Blood Cells

Seeking healthy adults and adults who have been suffering influenza-like illness for no more than 14 days for a study of how the flu or flu-like infections affect their blood cells.

Healthy Volunteers Wanted.

Gender

Male/Female

Age

Adult

Compensation

Offered

Image of Robert Finberg

Infectious Diseases

Gender

Male/Female

Age

Adult

Compensation

Offered

Image of Robert Finberg

Infectious Diseases

Gender

Male/Female

Age

18 and older

Compensation

Offered

Image of Robert Finberg

Infectious Diseases

Gender

Male/Female

Age

18 and older

Compensation

Offered

Image of Robert Finberg

Infectious Diseases

Gender

Male/Female

Age

2-10 years old

Compensation

Offered

Image of Milka Koupenova

Infectious Diseases

Infectious Diseases

Covid-19 Plasma Registry

Seeking people, local to central Massachusetts, who are fully recovered from the new coronavirus to sign up to donate plasma to help current COVID-19 patients.

Infectious Diseases

Convalescent Plasma To Stem Coronavirus For Adults Exposed To Covid-19

Seeking men and women who are at high risk of developing COVID-19 following an exposure to an infected person for a study to evaluate whether convalescent plasma, which is made from blood donated from a person who has recovered from COVID-19, might prevent or lessen the severity of COVID-19.

Gender

Male/Female

Age

18 and older

Compensation

None

Image of Jonathan Gerber

Infectious Diseases

Infectious Diseases

Infectious Diseases

Infectious Diseases

Inflammation of Esophagus

Gender

Male/Female

Age

12 and older

Compensation

Offered

Image of David Cave

Inflammatory Bowel Disease

Gender

Male/Female

Age

Adult

Compensation

Offered

Image of David Cave

Inflammatory Bowel Disease

Gender

Male/Female

Age

Adult

Compensation

Offered

Image of David Cave

Inflammatory Bowel Disease

Gender

Male/Female

Age

Adult

Compensation

Offered

Image of David Cave

Kidney Cancer

Study Of Kidney Tumors In Younger Patients

Seeking Male & Female patients age 0-30 years who have a kidney tumor (an abnormal growth of cells or tissues in the kidney that may be benign or malignant) or a tumor outside the kidney called a malignant rhabdoid tumor or an extrarenal Wilms tumor.

Gender

Male/Female

Age

0-30 years

Compensation

None

Image of Stefanie Lowas

Kidney Cancer

Leukemia (AML)

Gender

Male/Female

Age

3 and under

Compensation

None

Image of Stefanie Lowas

Liver Cancer

Lung Cancer

Lung Cancer

Lung Cancer

Lung Cancer

Lung Diseases and Breathing

Study To Improve Communication With Patients On Ventilators

Seeking men and women with either normal airways or airways that have been difficult to manage while under anesthesia for a study of a voice test might reliably predict people whose airways may be difficult to manage during an operation.

Gender

Male/Female

Age

Adult

Compensation

None

Image of Jens Walz

Lung Diseases and Breathing

Gender

Male/Female

Age

Adult

Compensation

Offered

Image of Jens Walz

Lung Diseases and Breathing

Gender

Male/Female

Age

Adult

Compensation

None

Image of Jens Walz

Lung Diseases and Breathing

Gender

Male/Female

Age

12 and older

Compensation

Offered

Image of Stuart Levitz

Lung Diseases and Breathing

Macular Degeneration

Macular Degeneration And Other Related Ocular Disorders

Children and adults who either have macular degeneration or are closely related to someone who has macular degeneration are sought for a study of macular degeneration and other related ocular disorders to prevent visual loss and blindness for current and future generations

Healthy Volunteers Wanted.

Gender

Male/Female

Age

7 and older

Compensation

None

Image of Johanna Seddon

Mental Health

Gender

Male/Female

Age

Adult

Compensation

Offered

Image of Xiaoduo Fan

Mental Health

Study Of An Investigational Drug For Schizophrenia

Seeking men and women who have been diagnosed with schizophrenia or schizoaffective disorder for a study of an investigational drug for negative symptoms, which are thoughts, feelings, or behaviors normally present that are absent or diminished in people with schizophrenia or schizoaffective disorder.

Gender

Male/Female

Age

18-55

Compensation

None

Image of Xiaoduo Fan

Mental Health

Gender

Male/Female

Age

18-75

Compensation

Offered

Image of John Haran

Mental Health

Mental Health

Gender

Male/Female

Age

Adult

Compensation

Offered

Image of Donna Perry

Mental Health

Mental Health

Mental Health

Mindfulness Study

Mindfulness Heart Study

Seeking men & women 18 years old and over who have a cardiomyopathy (impairment of your heart muscle strength) from coronary artery disease (hardening of the arteries).

Multiple Sclerosis

Multiple Sclerosis

Traditional Versus Early Therapy for Multiple Sclerosis (TREAT-MS) Trial

Newly diagnosed (within 6 months) people with Multiple Sclerosis (MS) sought for a trial comparing "first line" (traditional) with "second line" (aggressive) treatments in preventing disability. This is a pragmatic trial which means that even though participants will be randomly assigned a treatment group, they and their doctor can change their treatment if needed.

Multiple Sclerosis

Neuroblastoma

Neuroblastoma

Gender

Male/Female

Age

0 - 18 months

Compensation

None

Image of Stefanie Lowas

Neuroblastoma

Gender

Male/Female

Age

All

Compensation

None

Image of Stefanie Lowas

Nonalcoholic Steatohepatitis

Reverse: A Study Of An Investigational Drug For Compensated Cirrhosis Due To Nonalcoholic Steatohepatitis (Nash)

Nonalcoholic Steatohepatitis (NASH) results when fat accumulates in the liver and causes inflammation and scarring called fibrosis. Fibrosis can lead to cirrhosis which impairs liver function. Ocaliva (OCA) is an FDA approved drug for treating another type of liver disease. This study will test if Ocaliva (OCA) is safe and effective in treating cirrhosis of the liver caused by advanced NASH.

Nonalcoholic Steatohepatitis

Aurora: A Study Of An Experimental Drug For Liver Scarring Caused By Nash

Nonalcoholic Steatohepatitis (NASH) is a disease that results when fat accumulates in the liver and eventually causes inflammation and scarring called fibrosis. The purpose of this study is to test whether an experimental drug, CVC, is safe and effective in treating advanced scarring of the liver due to NASH.

Gender

Male/Female

Age

18+

Compensation

Offered

Image of Curtis Barry

Opioid Overdose

Gender

Male/Female

Age

Adult

Compensation

Offered

Image of Kavita Babu

Pediatrics

Peripheral Artery Disease

Prostate Cancer

Experimental Treatment for Metastatic Prostate Cancer

This study is looking at an experimental treatment for prostate cancer that has spread to other parts of the body and has grown even though treatments to lower the amount of male sex hormones are being used to manage the cancer.

Prostate Cancer

Pyruvate Kinase

Rectal Cancer

Rectal Cancer

Rectal Cancer Surgery Research

Seeking adults with rectal cancer requiring surgery for a study comparing an investigational surgery to the standard surgery technique

Reproductive and Women Health

Study To Develop A Screening Test For Preeclampsia In Pregnant Women

Pregnant women who are in their late 2nd to 3rd trimester who have high blood pressure are sought for a study to develop a screening test for preeclampsia in pregnant women. We will collect samples of your blood, urine, and saliva to see if we can detect levels of a protein that would help accurately predict who will get preeclampsia.

Reproductive and Women Health

Study Of The Effects Of High Blood Pressure During Pregnancy

Pregnant women with either normal or high blood pressure sought for a study of the effects of high blood pressure during pregnancy. The study will assess whether future cardiovascular disease or serious pregnancy complications like preeclampsia can be better detected & prevented.

Healthy Volunteers Wanted.

Rhabdomyosarcoma

Gender

Male/Female

Age

Up to 40 Years

Compensation

None

Image of Stefanie Lowas

Rheumatoid Arthritis

Rheumatoid Arthritis

Gender

Male/Female

Age

18 or older

Compensation

Offered

Image of Jonathan Kay

Skin and Hair Diseases

Study Involving Clinical Patch Testing Of Skin

Looking for adult volunteers 18 years of age or older with no history of any chronic skin diseases for a research study using clinical patch testing to see their skin’s response to chemical allergens.

Healthy Volunteers Wanted.

Gender

Male/Female

Age

18 and older

Compensation

Offered

Image of John Harris

Skin and Hair Diseases

Gender

Male/Female

Age

6yrs-Adults

Compensation

Offered

Image of John Harris

Skin and Hair Diseases

Skin and Hair Diseases

Study Of Skin Diseases Related To Your Immune System

Seeking people of all ages to participate in an observational study of immune-mediated skin diseases like Atopic Dermatitis, Psoriasis, Alopecia, Vitiligo, Hidradenitis Suppurativa and others. In this type of study we look at your medical history, but do not change the way you are being treated by your doctor.

Stem Cell Transplant

Stem Cell Transplant

Stroke

Experimental Treatment for Strokes

This study is looking at an experimental treatment for patients diagnosed with a stroke caused by a blockage in the blood vessels within the brain.

Stroke

Stroke

Study Of Drug Therapy To Prevent Stroke From Happening Again

Seeking Ischemic (caused by reduced blood flow by narrowed or blocked arteries) stroke survivors aged 45 and older for a study of an investigational therapy using anticoagulant drugs (aspirin or apixiaban) for the prevention of another stroke

Suicide Risk

Surgery

Gender

Male/Female

Age

Adult

Compensation

None

Image of Jens Walz

Surgery

Gender

Male/Female

Age

Adult

Compensation

Offered

Image of John Kelly

Surgery

Tissue Injury

Portable Hyperspectral Imaging (Hsi) Study

Seeking Men and Women 18 years or older patients who are having an operation that will require the creation of a flap of tissue (where a piece of skin/muscle is taken from one part of the body and moved to another part), or because you have a traumatic degloving injury (an injury where the skin is torn away from the tissue underneath).

Type 1 Diabetes Mellitus

Uterine Study

Vitiligo