Seeking healthy volunteers who either drink less than 1 drink per week on average or at least 3 drinks per day for a study collecting biological samples (blood, urine, and stool) and health information to better understand alcoholic hepatitis.
This study is looking at an experimental treatment for patients with anal cancer who have been treated with standard chemotherapy and radiation.
Seeking Men and Women 18-65 years old who have a fistula-in-ano that needs treatment.
Seeking adults with Ankylosing Spondylitis, a chronic disease that causes bones in the hip and spine to erode, for a study of the effectiveness of an investigational drug in treating the disease
Seeking men and women over the age of 18 who have been diagnosed with an aortic aneurysm (bulging of the vein that carries blood to your heart) that because of their anatomy can't be treated using an FDA-approved graft. This study would use endografts that are customized by the doctor to the anatomy of each patient to treat these complex aortic aneurysms.
Stroke survivors aged 50 and over sought for a study to develop and test a wearable sensor to monitor for atrial fibrillation (abnormal heartbeats)
Seeking men and women 18 years and older who have undergone a successful replacement of narrowed aortic valve and require treatment with oral blood thinners.
Seeking children aged 5-17 years with an Autism Spectrum Disorder (ASD) for a study of the safety and effectiveness of investigational drug to treat social behavior and communication deficits.
Seeking adults with Systemic Lupus Erythematosus (SLE) for a study of an experimental dietary supplement to replenish omega-3, an essential nutrient that helps to prevent and manage heart disease.
All adults and children 6 - 17 years who have a skin condition such as vitiligo psoriasis, atopic dermatitis, or scleroderma or are a healthy control subject without the disease.
We are collecting skin and blood samples from people with autoimmune or inflammatory skin diseases, like vitiligo psoriasis, atopic dermatitis, or scleroderma and from healthy volunteers to study how these skin diseases start in immune cells and why they affect the skin
We are studying whether combining an investigational drug with standard chemotherapy and surgery is more effective than just the standard chemotherapy and surgery in treating bladder cancer.
Seeking men and women whose doctor has recommended surgery to relieve pain resulting from damage to a disc in their back being pushed out of place (herniated) for a study of an investigational device to prevent the disc from reherniating.
Seeking adults who have inflammatory arthritis and who are willing to provide data by answering questionnaires, giving a blood sample and donating leftover tissue samples for a study to help researchers better understand inflammatory arthritis.
Seeking men & women over 18 years old who have a blood disorder or malignancy to investigate normal and abnormal cell growth.
This study compares surgical treatment versus medical management (non-surgical treatment) for patients who have a malignant bowel obstruction.
Seeking men and women with Multiple Sclerosis for a study of the role of stress in multiple sclerosis and whether an 8-week mindfulness-based stress reduction (MBSR) program effects your sense of well-being, stress level, and how it may change your brain.
Seeking men and women whose multiple sclerosis has not responded well to previous treatment and whose doctor has decided to start treatment with cladribine tablets and stop treatment with an injectable drug.
Seeking men and women with relapsing multiple sclerosis whose doctors has decided to start treatment with clabridine tablets because other pills were not working well.
This study is enrolling men and women who have had a traumatic brain injury in order to compare outcomes when medical care is delivered based on either monitoring the pressure in the brain or monitoring both the pressure in the brain and the amount of oxygen in the brain.
Seeking men and women with multiple sclerosis for a study of an investigational drug for multiple sclerosis. This drug has not been tested in humans before.
Seeking men and women who are within 8 hours of first experiencing the symptoms of a stroke caused when blood flow to the brain is blocked by a blood clot or fatty buildup (plaque) for a study of an investigational device to restore blood flow in the brain.
Seeking men and women who are within the first few hours of experiencing an ischemic stroke (caused by a blood clot blocking blood flow to the brain) for a study comparing medication combinations to reduce the impact of the stroke.
Seeking Men and Women 18-90 years old who have a small ruptured or un-ruptured aneurysm in the head.
Seeking men and women with a bifurcation aneurysm in their brain for treatment using an investigational medical device.
Seeking men and women with a brain aneurysm treated with a medical device called a Flow Diverter to slow the flow of blood into the aneurysm to see how well a software helps a doctor predict if the aneurysm will get smaller and blood flow becomes fully blocked over a year.
Seeking patients with a brain aneurysm (a bubble in the wall of a vessel in your brain) who, with their doctor, decided to treat it using approved endovascular coils (thin metal springs that stay in the blood vessels in the brain).
Seeking volunteers who will have their brain aneurysm treated using a coil to prevent it from bursting for a study of the long term performance of the coil.
Seeking patients who have suffered a brain injury like ischemic stroke, intracerebral hemorrhage or subarachnoid hemorrhage for a study of an investigational medical device to prevent fever while in the hospital
This study is comparing two types of screening mammograms, Digital Mammograms and Tomosynthesis Mammograms, to see which is better for breast cancer screening.
Seeking men & women 18 - 70 years who have a history of node positive or high risk node negative breast cancer.
The study is open to men & women with triple negative breast cancer that have received chemotherapy prior to surgery, then had surgery to remove the breast cancer, and viable tumor was still seen in the surgery specimen.
Preterm Infants diagnosed with pauses in breathing (apnea of prematurity) and treated for intermittent hypoxia using caffeine sought for study of longer-term caffeine treatment
Seeking Male and Female age 0-25 years who may have cancer or another condition that is characterized by abnormal cell growth but may be benign (not cancer), or may already have been diagnosed with cancer.
This study is collecting tumor tissue, body fluids and blood samples from patients undergoing biopsies or surgery to gain a better understanding of different cancers.
Seeking people aged 3 to 25 with newly-diagnosed high-grade glioma whose brain tumor has been genetically tested to show that it does not have the H3, K27M and BRAF mutations for a study of an investigational drug. The study will compare whether adding the investigational drug to radiation and maintenance therapy is better than the usual treatment.
Seeking children and young adults whose CD22+ B-Acute Lymphoblastic Leukemia (B ALL) has come back (relapsed) after treatment or has not responded (refractory) for a study of an investigational drug. While the investigational drug has been approved for use adults with leukemia, it has not yet been approved for use in children.
This study will evaluate the safety and effectiveness of an investigational drug for multiple types of advanced cancer that haven't responded to treatment and have spread to other parts of the body (metastatic).
Men and women with advanced HPV throat cancer sought for a study comparing the outcomes for people who get chemotherapy and radiation followed by experimental immunotherapy to those who get chemotherapy and radiation followed by observation.
People with a type of Diffuse Large B-Cell Lymphoma called "Activated B Cell" that did not get better with treatment or has returned after previous treatment sought for a study of whether adding in an additional investigational drug makes the therapy better, the same or worse than the usual approach.
Women with stage III, IVA or IVB or recurrent endometrial cancer for a study adding an additional immunotherapy drug to the usual treatment lowers the chance of the cancer growing or spreading.
Seeking men whose prostate cancer has spread beyond their prostate despite treatment with androgen deprivation therapy (also known as castration resistant prostate cancer) for a study comparing the usual treatment to the usual treatment with an experimental drug on controlling the cancer.
Seeking men whose prostate cancer has progressed despite previous treatment with hormone therapy and chemotherapy (also known as castration resistant prostate cancer) for a study comparing treatment using an investigational drug combination to treatment using one of two different usual treatments for metastatic prostate cancer.
This research is collecting data on nicotine cravings in patients with chronic pancreatitis who smoke cigarettes.
This study is looking at an experimental drug for patients with chronic inflammation of the pancreas.
Seeking adults 18 years or older who have had 3 or more infections with Clostridium difficile (CDI) in the past 9 months including at the time they join the study. Half of the participants will be given the study drug and the other half will be given a placebo (fake pill). You cannot choose and will not be told which group you are in while in the study.
Participants of the SERES-012 study may decide at Week 8 (if eligible) to join SERES-013, a follow on study in which all participants will receive the study drug.
This is an observational study of patients with cystic fibrosis. Any patient diagnosed with cystic fibrosis can participate.
Seeking male & females 16 years or older who are Hematopoietic Stem Cell Transplant (HSCT) recipients with asymptomatic Cytomegalovirus (CMV) infections
Study of whether treatment of congenital cytomegalovirus (cCMV) in infants who have experienced hearing-impairment reduces the loss in left or right ear hearing.
Seeking adults with degenerative spondylolisthesis with lumbar spinal stenosis whose doctors have recommended back surgery to address the pressure on your spinal cord or spinal nerves
Seeking men and women with a clostridium difficile infection (CDI), also called C. Difficile or C. Diff, that has returned at least once for a study to see if an experimental drug is better than nothing in preventing additional episodes of CDI.
We are collecting data and biological samples from people with infectious or inflammatory conditions of the bowel such as celiac disease, colitis, and Inflammatory Bowel Disease (IBD) and from people who do not have bowel disease to get a better understanding of these diseases.
Seeking people whose recurrent Clostridium difficile (C. diff) infection has not responded to standard antibiotic treatments for a study to see if fecal microbiota transplantation is effective for treating C. diff infection.
People who have shown signs of bleeding in their stomach or intestines sought for a study of a video camera capsule to diagnose gastrointestinal bleeding.
People whose perinanal fistula resulting from crohn's disease has not healed with treatment sought for a study of an investigational therapy using stem cells.
This study is intended to collect data from medical records on patients who have Duchenne Muscular Dystrophy
We are studying how well active surveillance, or two different combinations of chemotherapy work in treating children 11 and older and adults under age 25 with germ cell tumors.
Seeking women with ovarian cancer for a study of whether adding investigational drugs to the usual treatment delays or prevents ovarian cancer from coming back
Seeking adult men and women who have heart failure and are at risk of having episodes of worsening heart failure for a study of an implanted heart pressure sensor.
Seeking adult men and women with Critical Limb Ischemia for a study of the safety and effectiveness of an experimental treatment using stem cells collected from your own blood and injected into your muscles in your legs and foot to relieve symptoms.
Volunteers who are at risk for having heart disease, taking aspirin, and will be or have already undergone a cardiac catheterization sought for a study of how the body makes blood clots and its effect on the risk for heart attack and stroke.
Seeking adults with heart disease who are taking an aspirin to prevent blood clots from forming for a study of an investigational drug to assess if it prevents cells other than platelets from making thromboxane, a natural molecule made by your body to help blood to clot.
Men and women whose heart arteries have significant narrowing requiring treatment sought for a study comparing two systems to guide implentation of a stent to relieve blocked blood flow to your heart.
Seeking men and women who are within 10 hours from the time they started to have stroke symptoms for a study of how well people who get the investigational drug in additional to the usual treatment recover compared to people who get a medicine without any active drug (placebo) in addition to the usual treatment.
Seeking adult patients whose doctor has ordered a test called a Cardiac Catheterization to check for and possibly fix blockages in the heart. The doctor performing the cardiac catheterization will decide which patients who volunteer for the study are suitable participants.
This registry of heart attack survivors who had an IMPELLA pump temporarily implanted in their heart will collect medical information to help improve the quality of care of future heart attack survivors.
This is an observational study collecting information about patients diagnosed with chronic Hepatitis C viral (HCV) infection who are being treated with approved anti-HCV therapies. The purpose of this research study is to collect information about patients who are being treated for chronic hepatitis C virus (HCV).
Seeking blood samples from healthy volunteers and volunteers who have various autoimmune diseases, like type 1 diabetes
People with and without diabetes are sought for a study of an investigational device to screen for diabetes control by measuring acetone in their breath.
Seeking healthy adults and adults who have been suffering influenza-like illness for no more than 14 days for a study of how the flu or flu-like infections affect their blood cells.
Seeking people aged 12 and older with Eosinophilic Esophagitis (EoE) for a study of an investigational drug to treat esophageal inflammation. Some study volunteers will be randomly assigned to get the investigational drug and others will get a pill that does not have any medication (placebo)
Seeking volunteers age 18-75 years with Moderate to Severe Ulcerative Colitis to test two investigational medications to see if they are more effective than a pill that has no medication in it (placebo) at treating Ulcerative Colitis.
Seeking patients with moderate to severe Ulcerative Colitis. This study tests two amounts (doses) of a drug given by monthly injection compared with a fake medicine (placebo).
Seeking participants of the SHP647-301 or SHP647-302 studies for Ulcerative Colitis. This follow on study tests two amounts (doses) of the drug by monthly injection compared with a fake medicine (placebo).
Seeking participants of earlier studies investigating the drug SHP647 designed for treatment of Ulcerative Colitis and Crohn’s Disease. This follow on study tests the long term use of two doses of the drug by monthly injection.
Seeking adults 18-75 years old with moderate to severe Crohn's Disease for a study of two investigational medications to see if they are more effective than a pill without any medication (placebo) at treating Crohn's Disease.
Seeking patients with moderate to severe Crohn’s Disease. This study tests two amounts (doses) of a drug given by monthly injection compared with no treatment (placebo).
Seeking patients with moderate to severe Crohn’s Disease. This study tests two amounts (doses) of a drug by monthly injection compared with a fake injection (placebo).
This study is looking at an investigational treatment for patients who have been diagnosed with or have signs and symptoms of moderately to severely active Crohn’s disease.
This study is for patients diagnosed with moderately to severely active Crohn’s disease who have recently completed research study Receptos-3201 or Receptos-3202.
This study is for patients diagnosed with moderately to severely active Crohn’s disease who have recently completed a research study with the study drug.
Seeking adults who completed the AMAN clinical trial for active moderate to severe ulcerative colitis for a study of whether the investigational drug can make their ulcerative colitis go away and stay away over a year.
We are studying an investigational drug for the treatment of moderate to severe ulcerative colitis in people whose disease has not gotten better with other treatments.
Seeking adults who are being treated with the drug HUMIRA (Adalimumab) for their moderate to severe ulcerative colitis (UC) for a study of the long-term safety and effectiveness of the drug.
Seeking Male & Female patients age 0-30 years who have a kidney tumor (an abnormal growth of cells or tissues in the kidney that may be benign or malignant) or a tumor outside the kidney called a malignant rhabdoid tumor or an extrarenal Wilms tumor.
Seeking adults with localized (has not spread) kidney cancer who plan to undergo surgery to remove all or part of their kidney (nephrectomy) for a study comparing treatment with or without an investigational immunotherapy drug before surgery
Seeking males & females 1-31 years of age who have completed induction therapy for B Lymphoblastic Leukemia (B-ALL) & it has has been classified as a very high risk B-ALL (VHR B-ALL).
Seeking male & female patients 1-22 years of age who have been diagnosed with acute prolymphocytic leukemia (APL).
This study is looking at using different experimental treatment methods for children diagnosed with Acute Myeloid Leukemia (AML) and Down Syndrome (DS) based on how well they respond to their first treatment.
We are seeking people whose liver cancer was removed through surgery and radiation therapy for a study of an investigational drug to assess if it prevents the cancer from returning
The study drug, Ocaliva (OCA), already has FDA approval but we need to gather more data about how well it works on patients with Primary Biliary Cholangitis (PBC) when given along with the usual care for this condition. Half of the study participants will get the study drug and half will get a placebo (fake pill). You cannot choose or know which pill group you belong to.
Seeking Men and Women over 18 years old who have early stage non-small cell lung cancer that was surgically removed and may have been treated with chemotherapy and/or radiation. The tumor removed has a mutation of a gene called EGFR (Epidermal Growth Factor Receptor).
Seeking adult men & women whose tumor cells have a change in a gene called ALK that causes the cells to grow and spread.
Seeking Men and Women over 18 years old who have a certain type of Stage III Non-Small Cell Lung Cancer (NSCLC).
Seeking adults with non-small cell lung cancer for a study comparing immunotherapy to targeted therapy based on tumor characteristics
People with non-small cell lung cancer that has spread outside their lungs and whose tumor has a particular biomarker are sought for a study of an investigational drug.
Non-squamous non-small cell lung cancer patients whose cancer has been tested to be PD-L1 positive (a kind of tumor marker) sought for study comparing two usual approaches to treatment.
Seeking volunteers who received immunotherapy, but whose non-small cell lung cancer has spread outside their lungs and either their tumor sample biomarker does not match one of the open treatment studies or they were not a candidate for a biomarker-matched study for a study of an investigational drug combination.
Men and women with limited-stage small cell lung cancer, which has not spread outside of their chest area sought for a study comparing how cancer responds when adding an investigational drug to the usual treatment for small cell lung cancer
Seeking Men and Women 18 years or older who have small cell lung cancer, which can spread to the brain.
Seeking men and women with either normal airways or airways that have been difficult to manage while under anesthesia for a study of a voice test might reliably predict people whose airways may be difficult to manage during an operation.
Seeking intubated (tube placed in someone's throat to help them breath) people for a study collecting data about their communication with caregivers.
Seeking people with Cystic Fibrosis aged 12 and older for a study of blood, sputum, and/or leftover fluid collected during your bronchoscopy to look at how your body responds to infection or inflammation.
Children who have been intubated (breathing tube placed in their throat to help them breath) sought for a study comparing different doses of a sedative to keep them as comfortable as possible while they are recuperating.
Children and adults who either have macular degeneration or are closely related to someone who has macular degeneration are sought for a study of macular degeneration and other related ocular disorders to prevent visual loss and blindness for current and future generations
Men and women who arrive at the emergency department seeking care for either a medical or psychiatric condition may be asked to participate in a study of a screening survey to identify people at risk for suicide.
Seeking teens who live with Autism Spectrum Disorder (ASD) for a study to image their brains using magnetic resonance imaging (MRI) to better understand how their brains function.
Seeking men & women 18 years old and over who have a cardiomyopathy (impairment of your heart muscle strength) from coronary artery disease (hardening of the arteries).
This is a registry to collect medical record information from people living with Multiple Sclerosis (MS) to better understand the disease and develop new treatments
Seeking men and women with Multiple Sclerosis who completed the alemtuzumab Extension study for a new study of the long-term safety and effectiveness of alemtuzumab.
Newly diagnosed (within 6 months) people with Multiple Sclerosis (MS) sought for a trial comparing "first line" (traditional) with "second line" (aggressive) treatments in preventing disability. This is a pragmatic trial which means that even though participants will be randomly assigned a treatment group, they and their doctor can change their treatment if needed.
To collect data on patient who are receiving dimetyl fumarate as part of their routine care for multiple sclerosis
Volunteers who are participating in the NMTRC014 research study for treatment of neuroblastoma survivors who are in remission are sought for a research study of how the study drug is absorbed into the the body.
Seeking male and female children ranging from 0-18 months of age diagnosed with non-high risk neuroblastoma.
This study is for patients who may have neuroblastoma, a tumor of nerve cells typically found in the stomach, chest or neck of young children. This is a data and sample collection study to help us better understand this disease.
Nonalcoholic Steatohepatitis (NASH) is a disease that results when fat accumulates in the liver and eventually causes inflammation and scarring called fibrosis. The purpose of this study is to test whether an experimental drug, CVC, is safe and effective in treating advanced scarring of the liver due to NASH.
Nonalcoholic Steatohepatitis (NASH) is a disease that results when fat accumulates in the liver and eventually causes inflammation and scarring called fibrosis. The purpose of this study is to test whether an experimental drug, Elafibranor, is safe and effective in treating advanced scarring of the liver due to NASH.
Nonalcoholic Steatohepatitis (NASH) results when fat accumulates in the liver and causes inflammation and scarring called fibrosis. Fibrosis can lead to cirrhosis which impairs liver function. Ocaliva (OCA) is an FDA approved drug for treating another type of liver disease. This study will test if Ocaliva (OCA) is safe and effective in treating cirrhosis of the liver caused by advanced NASH.
Seeking adults who have experienced a near-fatal opioid overdose who would be willing to share their opinions about naltrexone treatment
This study is looking to enroll patients who are at a high risk of developing pancreatic cancer to see if taking an aspirin daily for one year can prevent or reduce the risk of developing cancer.
This study is collecting information from patients who are at a high risk of developing pancreatic cancer based on family history or genetic mutations to see if a pancreatic cancer screening blood test can be developed.
This study will evaluate the safety and effectiveness of an experimental drug to increase blood flow to legs for people with Critical Limb Ischemia who are not able to get surgical treatment.
This study is looking at an experimental treatment for prostate cancer that has spread to other parts of the body and has grown even though treatments to lower the amount of male sex hormones are being used to manage the cancer.
Volunteers with advanced prostate cancer that has spread to their bones sought for a study of an investigational drug to assess if it stops the cancer from growing
This is a registry of Pyruvate Kinase patients to study how the disease affects different people and how it is treated around the world.
This study is looking to compare different surgical options for treating patients with rectal cancer.
Seeking adults with rectal cancer requiring surgery for a study comparing an investigational surgery to the standard surgery technique
Pregnant women who are in their late 2nd to 3rd trimester who have high blood pressure are sought for a study to develop a screening test for preeclampsia in pregnant women. We will collect samples of your blood, urine, and saliva to see if we can detect levels of a protein that would help accurately predict who will get preeclampsia.
Pregnant women with either normal or high blood pressure sought for a study of the effects of high blood pressure during pregnancy. The study will assess whether future cardiovascular disease or serious pregnancy complications like preeclampsia can be better detected & prevented.
Seeking male & female patients who have been diagnosed with rhabdomyosarcoma (cancer that forms in the soft tissues, such as muscle).
This study is looking at a preventative medication for patients at risk of developing rheumatoid arthritis.
Seeking Men and Women 18 years or older who have completed a Gilead sponsored filgotinib parent study for RA GS-US-417-0303 for the treatment of Rheumatoid Arthritis (RA),
Seeking Men and Women 18-65 yeras old who have been diagnosed with schizophrenia or schizoaffective disorder who has not experienced a significant relief of symptoms in spite of being treated with one or more approved medicines for the treatment of their illness.
Seeking adults with Vitilgo for a study of an investigational topical gel to see if it is safe and effective for use on the skin of people with Vitiligo.
Seeking men and women who have a pressure ulcer that requires medical treatment to participate in a study of an investigational device for wound cleansing and protection.
Adult male and female U.S. recipients of allogeneic or autologous HSC transplants or cellular therapies are eligible to participate in the NMDP Research Sample Repository.
Men and women over 16 years old undergoing transplantation with unlicensed CBUs (cord blood units) will be enrolled. Cord blood units not meeting FDA requirements or not yet approved by the FDA may be used for transplant if the transplant is done as part of a study.
This study is looking at an experimental treatment for patients diagnosed with a stroke caused by a blockage in the blood vessels within the brain.
People who have been or will be treated with the Embotrap II revascularization device to remove blood clots to try to restore blood flow to the brain are being asked to participate in the EXCELLENT registry. This registry will collect and analyze the blood clots removed from the brain with the Embotrap II to study the different types of clots that cause stroke.
Seeking Ischemic (caused by reduced blood flow by narrowed or blocked arteries) stroke survivors aged 45 and older for a study of an investigational therapy using anticoagulant drugs (aspirin or apixiaban) for the prevention of another stroke
Study comparing two interventions to reduce suicidal behaviors and thoughts for people admitted to the emergency department or psychiatric unit of the hospital who recently attempted suicide or had suicidal thoughts
Adults aged 50 and older who have a planned abdominal, urologic, or other major surgery sought for a study on whether completing a walking exercise program before surgery improves surgical outcomes.
We are collecting information about pain and quality of life after hernia repair to better understand how to improve patient outcomes following surgery for hernia repair.
We are seeking men and women who will be undergoing total shoulder replacement surgery for a study comparing post-surgery pain between people who have the investigational drug added to the usual nerve block to people who just have the usual nerve block.
Seeking Men and Women 18 years or older patients who are having an operation that will require the creation of a flap of tissue (where a piece of skin/muscle is taken from one part of the body and moved to another part), or because you have a traumatic degloving injury (an injury where the skin is torn away from the tissue underneath).
This study is looking at whether taking vitamin D can help improve the symptoms of patients with type 1 diabetes.
This study is collecting tissue and information from pregnant women who are having cesarean births to gain a better understanding of how the uterus functions.
Seeking men & women who are 18 years or older who have been exposed to a chemical agent that has caused a skin condition called vitiligo, or worsened vitiligo/skin depigmentation (loss of skin color).
A study of how effective dermabrasion to remove the very top layer of skin on white spots located on your hands and wrists or feet and ankles is in treating vitiligo