Seeking men and women over the age of 18 who have been diagnosed with an aortic aneurysm (bulging of the vein that carries blood to your heart) that because of their anatomy can't be treated using an FDA-approved graft. This study would use endografts that are customized by the doctor to the anatomy of each patient to treat these complex aortic aneurysms.
168 Studies found
Stroke survivors aged 50 and over sought for a study to develop and test a wearable sensor to monitor for atrial fibrillation (abnormal heartbeats)
Investigational Drug To Treat Social Behavior And Communication Deficits In Children With Autism Spectrum Disorder
Seeking children aged 5-17 years with an Autism Spectrum Disorder (ASD) for a study of the safety and effectiveness of investigational drug to treat social behavior and communication deficits.
Study Of An Experimental Dietary Supplement To Improve Omega-3 Dietary Deficiency For People With Lupus
Seeking adults with Systemic Lupus Erythematosus (SLE) for a study of an experimental dietary supplement to replenish omega-3, an essential nutrient that helps to prevent and manage heart disease.
Seeking people who been diagnosed with Multiple Sclerosis (MS) or a similar immune disorder of the central nervous system or their immediate family members for a study to better understand what causes these diseases and perhaps improve treatment.
We are collecting skin and blood samples from people with autoimmune or inflammatory skin diseases, like vitiligo psoriasis, atopic dermatitis, or scleroderma and from healthy volunteers to study how these skin diseases start in immune cells and why they affect the skin
We are studying whether combining an investigational drug with standard chemotherapy and surgery is more effective than just the standard chemotherapy and surgery in treating bladder cancer.
Study Of An Investigational Implant To Prevent The Discs Between Backbone Vertebrae From Being Pushed Out (Herniating)
Seeking men and women whose doctor has recommended surgery to relieve pain resulting from damage to a disc in their back being pushed out of place (herniated) for a study of an investigational device to prevent the disc from reherniating.
Seeking adults with Ankylosing Spondylitis, a chronic disease that causes bones in the hip and spine to erode, for a study of the effectiveness of an investigational drug in treating the disease
Seeking adults who have inflammatory arthritis and who are willing to provide data by answering questionnaires, giving a blood sample and donating leftover tissue samples for a study to help researchers better understand inflammatory arthritis.
This study is intended to collect data from medical records on patients who have Duchenne Muscular Dystrophy
Seeking boys with Duchenne Muscular Dystrophy for a study of an investigational gene therapy drug.
Seeking young men aged 12 and older living with Duchenne Muscular Dystrophy (DMD) who are not able to walk and have been on a stable dose of corticosteroids for at least 6 months for a study of an investigational drug.
Seeking men & women over 18 years old who have a blood disorder or malignancy to investigate normal and abnormal cell growth.
Seeking men and women with Multiple Sclerosis for a study of the role of stress in multiple sclerosis and whether an 8-week mindfulness-based stress reduction (MBSR) program effects your sense of well-being, stress level, and how it may change your brain.
Seeking men and women whose multiple sclerosis has not responded well to previous treatment and whose doctor has decided to start treatment with cladribine tablets and stop treatment with an injectable drug.
Seeking men and women with relapsing multiple sclerosis whose doctors has decided to start treatment with clabridine tablets because other pills were not working well.
Seeking men and women with Amyotrophic Lateral Sclerosis (ALS) who have decided with their doctor to start taking the drug Edaravone to slow their symptom progression for a study of what changes happen in the blood and urine after they start taking the drug.
Seeking people with Parkinson's disease and healthy volunteers for a study of how speech changes depending on PD symptoms, effects of medication and genetics.
This study is enrolling men and women who have had a traumatic brain injury in order to compare outcomes when medical care is delivered based on either monitoring the pressure in the brain or monitoring both the pressure in the brain and the amount of oxygen in the brain.
Seeking men and women with multiple sclerosis for a study of an investigational drug for multiple sclerosis. This drug has not been tested in humans before.
Study Of Multiple Investigational Drugs To Prevent Progression Of Amyotrophic Lateral Sclerosis (Als)
Seeking men and women with Amyotrophic Lateral Sclerosis (ALS) to participate in a research trial to test several different investigational treatments.
Seeking men and women who are experiencing acute ischemic strokes caused by a blood clot blocking blood flow to a major artery in their brain for a study of an investigational device to remove the blood clot.
Seeking men and women who are participating in the ARCADIA stroke prevention trial for a study of the effect of the study drugs Apixaban and Aspirin on the occurrence of silent strokes and memory loss.
Seeking men and women who are within the first few hours of experiencing an ischemic stroke (caused by a blood clot blocking blood flow to the brain) for a study comparing medication combinations to reduce the impact of the stroke.
Seeking women and men who have started ocrelizumab treatment for their Multiple Sclerosis (MS) within the past month or people whose MS is being being treated with therapies other than ocrelizumab for a study looking at the incidence of cancer in the future.
Seeking men and women aged 50 and older who have had bleeding in the brain (brain hemorrhage) for a study comparing continuing or stopping statin drug use treatment on the risk of having another brain hemorrhage.
Seeking Men and Women 18-90 years old who have a small ruptured or un-ruptured aneurysm in the head.
Seeking men and women with a bifurcation aneurysm in their brain for treatment using an investigational medical device.
Seeking men and women with a brain aneurysm treated with a medical device called a Flow Diverter to slow the flow of blood into the aneurysm to see how well a software helps a doctor predict if the aneurysm will get smaller and blood flow becomes fully blocked over a year.
Seeking patients with a brain aneurysm (a bubble in the wall of a vessel in your brain) who, with their doctor, decided to treat it using approved endovascular coils (thin metal springs that stay in the blood vessels in the brain).
Seeking volunteers who will have their brain aneurysm treated using a coil to prevent it from bursting for a study of the long term performance of the coil.
Seeking patients who have suffered a brain injury like ischemic stroke, intracerebral hemorrhage or subarachnoid hemorrhage for a study of an investigational medical device to prevent fever while in the hospital
Preterm Infants diagnosed with pauses in breathing (apnea of prematurity) and treated for intermittent hypoxia using caffeine sought for study of longer-term caffeine treatment
Seeking Male and Female age 0-25 years who may have cancer or another condition that is characterized by abnormal cell growth but may be benign (not cancer), or may already have been diagnosed with cancer.
This study is collecting tumor tissue, body fluids and blood samples from patients undergoing biopsies or surgery to gain a better understanding of different cancers.
Seeking people aged 3 to 25 with newly-diagnosed high-grade glioma whose brain tumor has been genetically tested to show that it does not have the H3, K27M and BRAF mutations for a study of an investigational drug. The study will compare whether adding the investigational drug to radiation and maintenance therapy is better than the usual treatment.
Study Of An Investigational Drug For Relapsed Or Refractory Cd22+ B-Acute Lymphoblastic Leukemia (B All)
Seeking children and young adults whose CD22+ B-Acute Lymphoblastic Leukemia (B ALL) has come back (relapsed) after treatment or has not responded (refractory) for a study of an investigational drug. While the investigational drug has been approved for use adults with leukemia, it has not yet been approved for use in children.
Study Of Chemotherapy For Children And Young Adults With High-Risk B-Cell Acute Lymphoblastic Leukemia (B-All)
Children and young adults up to age 25 with High-Risk B-cell acute lymphoblastic leukemia (B-ALL) sought for a study of an investigational drug in combination of chemotherapy based on individual disease characteristics to improve 5-year disease-free survival (DFS).
Seeking children and young adults 31 years old or younger who have been newly diagnosed with standard risk B-cell Acute Lymphoblastic Leukemia (B-ALL), Down syndrome B ALL or localized B-cell Lymphoblastic Lymphoma (B-LLy) for a study of chemotherapy.
Seeking men and women who are or have been smokers and are at greater risk for lung cancer for a study to improve lung cancer screening
Study Of The Addition Of An Investigational Drug To Treatment Following Stem Cell Transplant For Multiple Myeloma
Seeking men and women who have had stem cell transplant for their multiple myeloma for a study of an investigational drug to be added to the usual maintenance treatment.
This study will evaluate the safety and effectiveness of an investigational drug for multiple types of advanced cancer that haven't responded to treatment and have spread to other parts of the body (metastatic).
Men and women with advanced HPV throat cancer sought for a study comparing the outcomes for people who get chemotherapy and radiation followed by experimental immunotherapy to those who get chemotherapy and radiation followed by observation.
Study Of A Targeted Investigational Drug For Non-Small Cell Lung Cancer That Has Come Back Or Spread After Treatment
Seeking men and women whose non-small cell lung cancer has come back or spread after treatment for a study of an investigational drug that is targeted for tumors with a specific biologic marker.
Study Of The Safety And Efficacy Of An Investigational Drug For Inoperable Early Stage Non Small Cell Lung Cancer
Seeking men and women with early stage (I/IIA) non small cell lung cancer that can't be removed with surgery for a study of an experimental drug.
Seeking men and women with HER2-positive breast cancer that has spread to other parts of the body (metastatic) for a study of an investigational drug.
Seeking men and women with pancreatic cancer for a study of an experimental device used along with chemotherapy to evaluate whether it decreases cancer cell growth.
Seeking men and women with locally advanced pancreatic cancer that can't be completely removed with surgery for a study of an investigational drug added to the standard chemotherapy.
Seeking men and women over the age of 70 whose pancreatic cancer has spread to other parts of their body for a study comparing two different drug combination therapies.
People with a type of Diffuse Large B-Cell Lymphoma called "Activated B Cell" that did not get better with treatment or has returned after previous treatment sought for a study of whether adding in an additional investigational drug makes the therapy better, the same or worse than the usual approach.
Seeking men and women whose chronic lymphocytic leukemia (CLL), small lymphocytic lymphoma (SLL), or non-Hodgkin's lymphoma can no longer be managed with the standard treatment for a study of the safety and effectiveness of an investigational drug.
The study is open to men & women with triple negative breast cancer that have received chemotherapy prior to surgery, then had surgery to remove the breast cancer, and viable tumor was still seen in the surgery specimen.
Seeking women with advanced high-grade epithelial ovarian, primary peritoneal, or fallopian tube cancers with high folate-receptor-alpha expression for a study comparing an investigational drug to chemotherapy.
Seeking men and women aged 18 and older whose colon, peritoneal, or rectal cancer will be treated with surgery (resectable) for a study of an investigational drug to make the cancer cells glow under infrared light.
Seeking men and women with cancer of the esophagus or gastric junction for a study of whether a blood sample analyzed to find evidence of a cancer tumor (liquid biopsy) might be a useful tool to predict how well the cancer has responded to treatment.
Seeking men and women with advanced (Stage III or IV) melanoma for a study of whether adding an investigational drug to an FDA approved drug combination is safe and effective.
This study is looking at an experimental treatment for patients with anal cancer who have been treated with standard chemotherapy and radiation.
Seeking men and women who have been diagnosed with melanoma skin cancer and will have surgery to remove it for a study of whether starting the experimental drug before surgery is better or worse than starting the drug after surgery.
Study Of An Investigational Drug For Metastatic Prostate Cancer That Is Resistant To Hormone Treatment
Seeking men whose prostate cancer has spread beyond their prostate despite treatment with androgen deprivation therapy (also known as castration resistant prostate cancer) for a study comparing the usual treatment to the usual treatment with an experimental drug on controlling the cancer.
Seeking men or women living with cancer of the bile duct, also known as cholangiocarcinoma, who need to change therapies for a study of the safety and effectiveness of an investigational drug either on its own or in combination with other drugs.
Seeking persons aged 12 and older who have a bloodstream infection related to a central venous catheter (CVC) for a study of an investigational drug to disinfect the catheter.
This research is collecting data on nicotine cravings in patients with chronic pancreatitis who smoke cigarettes.
This is an observational study of patients with cystic fibrosis. Any patient diagnosed with cystic fibrosis can participate.
Study of whether treatment of congenital cytomegalovirus (cCMV) in infants who have experienced hearing-impairment reduces the loss in left or right ear hearing.
Seeking adults with degenerative spondylolisthesis with lumbar spinal stenosis whose doctors have recommended back surgery to address the pressure on your spinal cord or spinal nerves
A Study Of An Experimental Physical Activity And Healthy Eating Program For Children With Intellectual Disabilities
Seeking children aged 12 to 16 years old with intellectual disabilities for a weekly after school experimental program teaching physical activity and healthy eating.
We are collecting data and biological samples from people with infectious or inflammatory conditions of the bowel such as celiac disease, colitis, and Inflammatory Bowel Disease (IBD) and from people who do not have bowel disease to get a better understanding of these diseases.
Study To Reduce The Risk Of Clostridium Difficile (C-Diff) Infection Among Long-Term Care Facility Patients
Seeking men and women aged 65 and older for a study of changes in the microbiome in the intestines of seniors when they move into a long-term care facility.
Seeking people whose recurrent Clostridium difficile (C. diff) infection has not responded to standard antibiotic treatments for a study to see if fecal microbiota transplantation is effective for treating C. diff infection.
Seeking men and women who are experiencing recurring fluid buildup in their abdomen due to liver cirrhosis for a study of an implanted investigational device to drain the excess fluid.
People who have shown signs of bleeding in their stomach or intestines sought for a study of a video camera capsule to diagnose gastrointestinal bleeding.
Seeking men and women for whom their doctor has ordered an upper endoscopy to diagnose upper gastrointestinal symptoms for a study of an investigational imaging device.
Seeking Men and Women 18-65 years old who have a fistula-in-ano that needs treatment.
Study Of An Investigational Therapy Using Stem Cells For Perianal Fistulas In People With Crohn's Disease
People whose perinanal fistula resulting from crohn's disease has not healed with treatment sought for a study of an investigational therapy using stem cells.
Seeking healthy volunteers who either drink less than 1 drink per week on average or at least 3 drinks per day for a study collecting biological samples (blood, urine, and stool) and health information to better understand alcoholic hepatitis.
Seeking men and women whose primary biliary cholangitis is causing them moderate to severe itchiness for a study of an investigational drug.
Study Of An Investigational Drug For Geographic Atrophy Associated With Dry Age-Related Macular Degeneration
Seeking men and women with an eye condition called geographic atrophy (GA) secondary to dry age- related macular degeneration (AMD) for a study of an investigational drug.
We are studying how well active surveillance, or two different combinations of chemotherapy work in treating children 11 and older and adults under age 25 with germ cell tumors.
Study Of The Differences Between People Having A Heart Attack And People Suffering Stress Cardiomyopathy
Seeking men and women who are experiencing symptoms of a heart attack including chest pain and shortness of breath for a study of the effect of stress on heart function and the development of stress cardiomyopathy.
Seeking adult men and women who have heart failure and are at risk of having episodes of worsening heart failure for a study of an implanted heart pressure sensor.
Study Of An Experimental Treatment Using Stem Cells Collected From Your Blood For People With Critical Limb Ischemia
Seeking adult men and women with Critical Limb Ischemia for a study of the safety and effectiveness of an experimental treatment using stem cells collected from your own blood and injected into your muscles in your legs and foot to relieve symptoms.
Volunteers who are at risk for having heart disease, taking aspirin, and will be or have already undergone a cardiac catheterization sought for a study of how the body makes blood clots and its effect on the risk for heart attack and stroke.
Study Of An Investigational Drug To Prevent Blood Clots And Elevated Blood Pressure In People With Heart Disease
Seeking adults with heart disease who are taking an aspirin to prevent blood clots from forming for a study of an investigational drug to assess if it prevents cells other than platelets from making thromboxane, a natural molecule made by your body to help blood to clot.
Seeking men and women whose carotid arteries have narrowed for a study of an intense medical management plan to reduce risk factors for stroke including high blood pressure, high cholesterol, diabetes, and smoking.
Seeking men and women who will be undergoing a medical procedure to remove a blood clot or blockage from an artery that is blocking blood flow to the brain (ischemic stroke) for a study of the technical use and safety of a device used during the procedure.
Seeking men and women who are within 10 hours from the time they started to have stroke symptoms for a study of how well people who get the investigational drug in additional to the usual treatment recover compared to people who get a medicine without any active drug (placebo) in addition to the usual treatment.
Seeking men and women who are about to start a taking a pill to help thin their blood (called an anticoagulant) for a study of whether adding a clinical pharmacist to the study team improves care.
Seeking adult patients whose doctor has ordered a test called a Cardiac Catheterization to check for and possibly fix blockages in the heart. The doctor performing the cardiac catheterization will decide which patients who volunteer for the study are suitable participants.
Seeking blood samples from healthy volunteers and volunteers who have various autoimmune diseases, like type 1 diabetes
Seeking men and women who are willing to donate fat cells for a study of the difference between fat cells collected from healthy volunteers and people who have type 2 diabetes.
Seeking boys and girls under the age of 18 who are hospitalized for a COVID-19 infection for a study of the safety and effectiveness of remdesivir for COVID-19 infection in children.
Study Of An Investigational Dietary Supplement In People Treated Outside Of The Hospital For Covid-19 Infection
Seeking men and women with mild to moderate COVID-19 infection to investigate the potential benefits of a specially formulated probiotic to treat gastrointestinal symptoms related to COVID-19.
Seeking healthy adults and adults who have been suffering influenza-like illness for no more than 14 days for a study of how the flu or flu-like infections affect their blood cells.
Study Of The Safety And Efficacy Of Investigational Monoclonal Antibodies For Mild To Moderate Covid-19 (Blaze-1)
Seeking individuals over 12 years of age with mild to moderate COVID-19 illness, but have not yet been hospitalized for a study of investigational monoclonal antibodies against COVID-19.
Study Of An Investigational Drugs Containing Monoclonal Antibodies For Mild To Moderate Covid-19 (Blaze 4)
Seeking men and women with mild to moderate COVID-19 for a study of an investigational drug that contains monoclonal antibodies.
Seeking men and women who have been hospitalized with COVID-19 for a study that compares the safety and activity of experimental regimens consisting of oral anti-inflammatory agents plus Remdesivir.
Seeking children who have been diagnosed with influenza in the past 7 days and healthy children willing to donate a blood sample for a study of how influenza affects blood cells of children.
Seeking people, local to central Massachusetts, who are fully recovered from the new coronavirus to sign up to donate plasma to help current COVID-19 patients.
Seeking men and women who are at high risk of developing COVID-19 following an exposure to an infected person for a study to evaluate whether convalescent plasma, which is made from blood donated from a person who has recovered from COVID-19, might prevent or lessen the severity of COVID-19.
Convalescent Plasma To Limit Coronavirus Associated Complications For People Being Treated Outside The Hospital
Seeking men and women who are being treated outside of the hospital for their COVID-19 infection for a study of an investigational blood product made from blood plasma donated by people who have recovered from COVID-19, known as convalescent plasma.
Seeking people aged 12 and older who have been diagnosed with COVID-19 for an experimental treatment made from blood donated by people who have recovered from COVID-19.
Study Of An Experimental Treatment Using Hyperimmune Intravenous Immunoglobulin For Covid-19 In Hospitalized Adults
Seeking men and women aged 18 and older who have been hospitalized for COVID-19 for a study of an experimental treatment using Hyperimmune Intravenous Immunoglobulin containing antibodies for COVID-19.
Seeking adults and children for a study testing the accuracy of investigational devices to diagnose COVID-19.
Seeking people aged 12 and older with Eosinophilic Esophagitis (EoE) for a study of an investigational drug to treat esophageal inflammation. Some study volunteers will be randomly assigned to get the investigational drug and others will get a pill that does not have any medication (placebo)
This study is looking at an investigational treatment for patients who have been diagnosed with or have signs and symptoms of moderately to severely active Crohn’s disease.
This study is for patients diagnosed with moderately to severely active Crohn’s disease who have recently completed research study Receptos-3201 or Receptos-3202.
This study is for patients diagnosed with moderately to severely active Crohn’s disease who have recently completed a research study with the study drug.
Seeking Male & Female patients age 0-30 years who have a kidney tumor (an abnormal growth of cells or tissues in the kidney that may be benign or malignant) or a tumor outside the kidney called a malignant rhabdoid tumor or an extrarenal Wilms tumor.
Seeking adults with localized (has not spread) kidney cancer who plan to undergo surgery to remove all or part of their kidney (nephrectomy) for a study comparing treatment with or without an investigational immunotherapy drug before surgery
This study is looking at using different experimental treatment methods for children diagnosed with Acute Myeloid Leukemia (AML) and Down Syndrome (DS) based on how well they respond to their first treatment.
We are seeking people whose liver cancer was removed through surgery and radiation therapy for a study of an investigational drug to assess if it prevents the cancer from returning
Seeking adult men & women whose tumor cells have a change in a gene called ALK that causes the cells to grow and spread.
Seeking adults with non-small cell lung cancer for a study comparing immunotherapy to targeted therapy based on tumor characteristics
Study Of Immunotherapy Alone Or In Combination With Chemotherapy For Advanced Nonsquamous Non-Small Cell Lung Cancer
Non-squamous non-small cell lung cancer patients whose cancer has been tested to be PD-L1 positive (a kind of tumor marker) sought for study comparing two usual approaches to treatment.
Addition Of An Investigational Drug To The Usual Treatment For Limited Stage Small Cell Lung Cancer (Ls-Sclc)
Men and women with limited-stage small cell lung cancer, which has not spread outside of their chest area sought for a study comparing how cancer responds when adding an investigational drug to the usual treatment for small cell lung cancer
Seeking men and women with either normal airways or airways that have been difficult to manage while under anesthesia for a study of a voice test might reliably predict people whose airways may be difficult to manage during an operation.
Study Of An Assessment To Predict Which People Might Have A Difficult Airway To Manage During Surgery
Seeking men and women with either normal airways or airways that have been difficult to manage while under anesthesia for a study of a voice test that might reliably predict if someone's airway may be difficult to manage during an operation.
Seeking intubated (tube placed in someone's throat to help them breathe) people for a study of an investigational device to improve their communication with caregivers.
Study Of Body Fluid Samples From People With Cystic Fibrosis To Look At The Body's Response To Infection\ Inflammation
Seeking people with Cystic Fibrosis aged 12 and older for a study of blood, sputum, and/or leftover fluid collected during your bronchoscopy to look at how your body responds to infection or inflammation.
Children and adults who either have macular degeneration or are closely related to someone who has macular degeneration are sought for a study of macular degeneration and other related ocular disorders to prevent visual loss and blindness for current and future generations
Seeking men and women who have been diagnosed with schizophrenia or schizoaffective disorder and a substance use disorder for a study of an anti-psychotic medication to see it helps reduce substance cravings.
Seeking men and women who have been diagnosed with schizophrenia or schizoaffective disorder for a study of an investigational drug for negative symptoms, which are thoughts, feelings, or behaviors normally present that are absent or diminished in people with schizophrenia or schizoaffective disorder.
Seeking men and women who have been treated in the Emergency Department following a traumatic event or injury for a study to learn more about the recovery process.
Men and women who arrive at the emergency department seeking care for either a medical or psychiatric condition may be asked to participate in a study of a screening survey to identify people at risk for suicide.
Seeking veterans with post-traumatic stress disorder (PTSD) or PTSD symptoms for a study of an intervention to see if observing and caring for injured or orphaned wildlife at a wildlife rehabilitation center helps to reduce PTSD symptoms.
Seeking deaf adults and ASL users who is experiencing problems with alcohol use and trauma for an experimental intervention that we hope will reduce symptoms of addiction.
Seeking teens who live with Autism Spectrum Disorder (ASD) for a study to image their brains using magnetic resonance imaging (MRI) to better understand how their brains function.
All anesthesiology residents currently at UMass are invited to participate in an anonymous wellness survey
Seeking men & women 18 years old and over who have a cardiomyopathy (impairment of your heart muscle strength) from coronary artery disease (hardening of the arteries).
This is a registry to collect medical record information from people living with Multiple Sclerosis (MS) to better understand the disease and develop new treatments
Newly diagnosed (within 6 months) people with Multiple Sclerosis (MS) sought for a trial comparing "first line" (traditional) with "second line" (aggressive) treatments in preventing disability. This is a pragmatic trial which means that even though participants will be randomly assigned a treatment group, they and their doctor can change their treatment if needed.
Questionnaire Study Of The Long-Term Safety And Effectiveness Of The Drug Tecfidera For Multiple Sclerosis (Ms)
To collect data on patient who are receiving dimetyl fumarate as part of their routine care for multiple sclerosis
Volunteers who are participating in the NMTRC014 research study for treatment of neuroblastoma survivors who are in remission are sought for a research study of how the study drug is absorbed into the the body.
Seeking male and female children ranging from 0-18 months of age diagnosed with non-high risk neuroblastoma.
This study is for patients who may have neuroblastoma, a tumor of nerve cells typically found in the stomach, chest or neck of young children. This is a data and sample collection study to help us better understand this disease.
Reverse: A Study Of An Investigational Drug For Compensated Cirrhosis Due To Nonalcoholic Steatohepatitis (Nash)
Nonalcoholic Steatohepatitis (NASH) results when fat accumulates in the liver and causes inflammation and scarring called fibrosis. Fibrosis can lead to cirrhosis which impairs liver function. Ocaliva (OCA) is an FDA approved drug for treating another type of liver disease. This study will test if Ocaliva (OCA) is safe and effective in treating cirrhosis of the liver caused by advanced NASH.
Nonalcoholic Steatohepatitis (NASH) is a disease that results when fat accumulates in the liver and eventually causes inflammation and scarring called fibrosis. The purpose of this study is to test whether an experimental drug, CVC, is safe and effective in treating advanced scarring of the liver due to NASH.
Seeking adults who have experienced a near-fatal opioid overdose who would be willing to share their opinions about naltrexone treatment
Seeking teens aged 15-18 years old who were enrolled in the ELGAN study of premature infants between April 2002 and August 2004 for a follow-up study of health and developmental progress.
This study will evaluate the safety and effectiveness of an experimental drug to increase blood flow to legs for people with Critical Limb Ischemia who are not able to get surgical treatment.
This study is looking at an experimental treatment for prostate cancer that has spread to other parts of the body and has grown even though treatments to lower the amount of male sex hormones are being used to manage the cancer.
Volunteers with advanced prostate cancer that has spread to their bones sought for a study of an investigational drug to assess if it stops the cancer from growing
This is a registry of Pyruvate Kinase patients to study how the disease affects different people and how it is treated around the world.
This study is looking to compare different surgical options for treating patients with rectal cancer.
Seeking adults with rectal cancer requiring surgery for a study comparing an investigational surgery to the standard surgery technique
Pregnant women who are in their late 2nd to 3rd trimester who have high blood pressure are sought for a study to develop a screening test for preeclampsia in pregnant women. We will collect samples of your blood, urine, and saliva to see if we can detect levels of a protein that would help accurately predict who will get preeclampsia.
Pregnant women with either normal or high blood pressure sought for a study of the effects of high blood pressure during pregnancy. The study will assess whether future cardiovascular disease or serious pregnancy complications like preeclampsia can be better detected & prevented.
Seeking male & female patients who have been diagnosed with rhabdomyosarcoma (cancer that forms in the soft tissues, such as muscle).
This study is looking at a preventative medication for patients at risk of developing rheumatoid arthritis.
Seeking Men and Women 18 years or older who have completed a Gilead sponsored filgotinib parent study for RA GS-US-417-0303 for the treatment of Rheumatoid Arthritis (RA),
Looking for adult volunteers 18 years of age or older with no history of any chronic skin diseases for a research study using clinical patch testing to see their skin’s response to chemical allergens.
We are studying how skin diseases occur in the skin, including how immune cells choose to initiate disease as well as what causes them to enter the skin.
Seeking people of all ages to participate in an observational study of immune-mediated skin diseases like Atopic Dermatitis, Psoriasis, Alopecia, Vitiligo, Hidradenitis Suppurativa and others. In this type of study we look at your medical history, but do not change the way you are being treated by your doctor.
Seeking men and women with stable vitiligo for a study of an investigational device for transplanting healthy skin cells to return skin color to areas that have lost their pigmentation due to stable vitiligo.
Adult male and female U.S. recipients of allogeneic or autologous HSC transplants or cellular therapies are eligible to participate in the NMDP Research Sample Repository.
Men and women over 16 years old undergoing transplantation with unlicensed CBUs (cord blood units) will be enrolled. Cord blood units not meeting FDA requirements or not yet approved by the FDA may be used for transplant if the transplant is done as part of a study.
This study is looking at an experimental treatment for patients diagnosed with a stroke caused by a blockage in the blood vessels within the brain.
People who have been or will be treated with the Embotrap II device to remove blood clots to try to restore blood flow to the brain are being asked to participate in the EXCELLENT registry. This registry will collect and analyze the blood clots removed from the brain with the Embotrap II to study the different types of clots that cause stroke.
Seeking Ischemic (caused by reduced blood flow by narrowed or blocked arteries) stroke survivors aged 45 and older for a study of an investigational therapy using anticoagulant drugs (aspirin or apixiaban) for the prevention of another stroke
Study comparing two interventions to reduce suicidal behaviors and thoughts for people admitted to the emergency department or psychiatric unit of the hospital who recently attempted suicide or had suicidal thoughts
Adults aged 50 and older who have a planned abdominal, urologic, or other major surgery sought for a study on whether completing a walking exercise program before surgery improves surgical outcomes.
We are collecting information about pain and quality of life after hernia repair to better understand how to improve patient outcomes following surgery for hernia repair.
Study Of An Investigational Drug To Improve Pain Management Following Total Shoulder Replacement Surgery
We are seeking men and women who will be undergoing total shoulder replacement surgery for a study comparing post-surgery pain between people who have the investigational drug added to the usual nerve block to people who just have the usual nerve block.
Seeking Men and Women 18 years or older patients who are having an operation that will require the creation of a flap of tissue (where a piece of skin/muscle is taken from one part of the body and moved to another part), or because you have a traumatic degloving injury (an injury where the skin is torn away from the tissue underneath).
This study is looking at whether taking vitamin D can help improve the symptoms of patients with type 1 diabetes.
This study is collecting tissue and information from pregnant women who are having cesarean births to gain a better understanding of how the uterus functions.
A study of how effective dermabrasion to remove the very top layer of skin on white spots located on your hands and wrists or feet and ankles is in treating vitiligo